We treat some of the most challenging immune-mediated conditions. These pages are here to help you understand your diagnosis, know what to expect, and find support.
CVID is one of the most common primary immunodeficiency disorders. Your B cells — the immune cells responsible for making antibodies — do not produce enough immunoglobulins (IgG, IgA, IgM) to protect you from infections.
Without adequate antibodies, your body has difficulty fighting off bacteria and viruses, leading to frequent or severe infections. CVID is a lifelong condition, but with the right treatment most patients live full, active lives.
The primary treatment is immunoglobulin replacement therapy (IgG), which replaces the antibodies your body cannot make on its own.
Infused in our state-of-the-art infusion center by specialized nurses. Typically every 3–4 weeks. Most covered by insurance with prior authorization.
Smaller doses given under the skin, often weekly or bi-weekly. Some patients self-administer at home after training from our nursing team.
For eligible patients, our home infusion program brings treatment to you. Fully coordinated by the Veros team — you don't have to manage it alone.
Regular IgG trough levels, infection tracking, and lung function monitoring ensure your dose stays optimized over time.
What to expect: IVIG infusions typically take 2–4 hours. Most patients feel noticeably better within a few months of starting therapy. Side effects are usually mild and manageable — tell your infusion nurse about any reactions.
Immune Deficiency Foundation — patient support, research, and advocacy
Jeffrey Modell Foundation — PI diagnosis and treatment resources
CVID Patient Support Network — community and condition-specific info
(303) 224-4900 · immunehealth.com
The Immune Connection: Long COVID is not a mystery — it is immune dysregulation. COVID-19 depletes B cells, triggers autoantibodies, activates mast cells via spike protein binding, and drives chronic inflammation. At Veros, we identify and treat these immune root causes — not just manage the symptoms.
⚠ Important — Post-Exertional Malaise (PEM): Do NOT push through fatigue. In Long COVID, overexertion causes crashes and worsening — a phenomenon called post-exertional malaise. Pacing — staying within your energy envelope — is the single most critical management strategy. Tell your Veros provider about any crashes after activity.
Long COVID refers to symptoms persisting 4+ weeks after COVID-19 infection — even a mild one. It affects multiple organ systems because the root cause is immune dysregulation, not organ damage alone.
COVID-19 can deplete antibody-producing B cells, trigger autoantibodies, activate mast cells, cause fibrin microclots that impair circulation, and leave the immune system in a chronic inflammatory state. This is why immune-targeted treatment gets results where general supportive care does not.
COVID depletes B cells and suppresses antibody production long-term. New-onset low IgG/IgA/IgM is well-documented post-COVID. IVIG therapy is effective and backed by an active Phase 2 clinical trial (NCT06159283).
Spike protein directly activates mast cells via ACE2 and IgE receptors. Post-COVID food intolerances, flushing, and histamine reactions are classic signs. Many Long COVID patients meet full MCAS diagnostic criteria.
One of the most common Long COVID sequelae. Autoantibodies against adrenergic receptors drive racing heart, lightheadedness, and presyncope on standing. Overlaps heavily with MCAS.
Post-exertional malaise (PEM) affects ~50% of Long COVID patients. Pacing, energy management, and avoiding aggressive exercise are critical. Graded Exercise Therapy (GET) can worsen this subset.
New-onset autoantibodies against thyroid, neural tissue, and phospholipids are documented post-COVID. New-onset lupus, Sjogren's, and antiphospholipid syndrome have been reported. Immune panel at Veros can identify these.
EBV, HHV-6, and other latent herpesviruses can reactivate post-COVID, driving ongoing immune activation, fatigue, and neurological symptoms. Testing available at Veros.
Autoantibody panels, IgG/IgA/IgM levels, B & T cell counts, inflammatory markers (CRP, ferritin, cytokines), and viral reactivation testing to identify your specific mechanism.
For patients with post-COVID hypogammaglobulinemia or autoimmune features — IVIG can be transformative. Validated by active Phase 2 trial (NCT06159283) specifically for Long COVID with B-cell impairment.
Baricitinib (JAK inhibitor) is in active Phase 3 trial REVERSE-LC (NCT06631287) for Long COVID neurological and cardiopulmonary symptoms. We follow emerging evidence closely.
If mast cell activation is identified — antihistamine regimen, mast cell stabilizers, and biologics (Xolair, Dupixent). Many Long COVID patients see significant improvement when MCAS is treated.
Hydration, sodium loading, compression, pyridostigmine (active trial at Brigham & Women's NCT06366724), and Low-Dose Naltrexone for autonomic and neuroinflammatory features.
Neurology, rheumatology, cardiology — all immune-focused and all coordinated through your Veros team. You do not have to manage fragmented specialty care alone.
You do not have to "just live with it." Long COVID has measurable immune and inflammatory drivers. Immune-targeted treatment gets results. Please tell your Veros provider every symptom you are experiencing — the full picture matters.
Fibrinolytic enzymes targeting the fibrin microclots documented in Long COVID. Lumbrokinase in active Phase 1/2 trial at Mt. Sinai (NCT06511050). Discuss with your Veros provider before starting.
Anti-neuroinflammatory and immune-modulating. Active in LIFT trial at Brigham & Women's (NCT06366724). Widely used in ME/CFS and MCAS overlap. Well-tolerated at low doses.
Mitochondrial support addressing the mitochondrial dysfunction documented in Long COVID fatigue. Often combined for synergistic effect.
Deficiency strongly associated with Long COVID severity. Immune-regulatory. Optimize to 50–80 ng/mL — ask your Veros provider to check your level.
Quercetin: mast cell stabilizer and zinc ionophore — especially valuable in MCAS overlap. NAC: glutathione precursor, antioxidant, supports immune regulation.
Omega-3: anti-inflammatory. Magnesium glycinate: supports sleep and nervous system (commonly depleted post-COVID). Methylated B12: nerve repair and energy metabolism.
Mediterranean-style: olive oil, fatty fish, colorful vegetables, legumes, nuts. Avoid ultra-processed foods, refined sugar, and trans fats. Reduces CRP, IL-6, and other inflammatory markers.
For patients with post-COVID food intolerances or flushing — avoid aged, fermented, and cured foods. See whatthebleep.com — our top recommended resource.
Track activity and energy in a pacing diary. Use heart rate monitoring to stay below your anaerobic threshold. Structured rest is treatment — not laziness.
Critical for POTS overlap: 2–3L fluid/day, 3–5g sodium/day. Electrolyte formulas (LMNT, Liquid IV) helpful. Compression garments and head-of-bed elevation for POTS symptoms.
Consistent sleep schedule, limit screens before bed, cool room. Melatonin, magnesium glycinate, and LDN can support sleep quality. Treat sleep apnea if present.
Vagus nerve stimulation, breathwork (box breathing, 4-7-8), mindfulness. Dysautonomia and nervous system dysregulation respond to autonomic retraining programs (Gupta Program, DNRS).
Long COVID Alliance — leading advocacy and research funding organization
Survivor Corps — patient community, research participation, and advocacy
NIH RECOVER Initiative — largest US Long COVID research program
FLCCC Alliance I-RECOVER protocol — comprehensive clinician and patient treatment guide
ME Association — essential resource for Long COVID + ME/CFS overlap and pacing guidance
Dysautonomia International — for POTS and autonomic dysfunction overlap
Patient-led weekly podcast covering symptoms, research, and practical management strategies
Patient advocacy stories and emerging research from a major Long COVID community
Patient community covering Long COVID science, policy, and lived experience
Dr. Linda Bluestein covers the Long COVID + hEDS + POTS + MCAS overlap — highly relevant for Veros patients
Dysautonomia International's podcast — covers POTS, Long COVID autonomic dysfunction extensively
Evidence-based immunology including Long COVID immune mechanisms and treatments
Current peer-reviewed literature on Long COVID immunology, mechanisms, and treatment
Active Long COVID trials — including IVIG (NCT06159283), baricitinib REVERSE-LC (NCT06631287), and LDN LIFT trial (NCT06366724)
Landmark paper defining Long COVID phenotypes and multi-organ involvement across 1.2M patients
Online communities offer peer support, practical tips, and connection with others who understand. Always verify medical information with your Veros provider.
One of the largest patient communities — 200,000+ members sharing experiences and tips
Active community with research updates, treatment discussions, and advocacy
Very active community — research sharing, treatment experiences, daily support
Additional Long COVID community with case discussions and peer support
Moderated health community with Long COVID-specific forums
For patients navigating the Long COVID + MCAS + POTS overlap
(303) 224-4900 · veroshealth.com
The Immune Connection: Mast cells are immune cells — MCAS is not just an allergy disorder, it is an immune system dysregulation. At Veros, we treat the full immune picture, including the common triad of MCAS, hEDS, and POTS/dysautonomia.
MCAS is an immunologic condition in which mast cells become too numerous or too easily activated. Mast cells reside throughout the body and when triggered release histamine, leukotrienes, prostaglandins, tryptase, and other inflammatory mediators — causing multi-system symptoms that often lack a clear trigger.
MCAS is frequently underdiagnosed because symptoms overlap with many other conditions. It commonly co-occurs with hEDS and POTS/dysautonomia — a triad seen frequently at Veros Health.
Detailed history and dietary/environmental review to identify and minimize your personal triggers. Common triggers include foods, fragrances, medications, stress, and temperature changes.
H1 blockers (Allegra, Zyrtec, Xyzal, Claritin) and H2 blockers (Pepcid) used strategically twice daily. Timing and combination matter as much as dose.
Cromolyn sodium and ketotifen prevent mast cell degranulation. Leukotriene inhibitors (Singulair) and Low-Dose Naltrexone may also be used.
Omalizumab (Xolair) — every 2–4 weeks, inhibits IgE-mediated mast cell activation. Dupilumab (Dupixent) — newly FDA-approved for MCAS, targets IL-4/IL-13 pathways. Ask your Veros provider if you are eligible.
Quercetin (mast cell stabilizer), Hist-DAO (Diamine Oxidase — degrades histamine), Vitamin C (degrades histamine), and Luteolin may reduce mediator burden.
At Veros, we evaluate and treat hEDS and POTS alongside MCAS — because in most patients, these conditions are deeply interconnected and must be managed together.
Every MCAS patient leaves Veros with: A personalized written emergency action plan, epinephrine auto-injector prescription, and clear guidance on when to treat at home versus go to the ER. You will not navigate this alone.
The Mast Cell Disease Society (TMS) — leading advocacy, research funding, and provider education for mast cell disorders
Mast Cell Action — UK-based patient charity with excellent plain-language resources applicable worldwide
Dysautonomia International — essential resource for the POTS/autonomic dysfunction overlap with MCAS
The Ehlers-Danlos Society — for patients navigating the hEDS side of the MCAS triad
American Academy of Allergy, Asthma & Immunology — clinical guidelines and patient resources
Immune Deficiency Foundation — for patients with immune overlap conditions
"What the Bleep Can I Eat" — our most recommended patient resource for low-histamine food guidance, lists, and practical tips
Mast Cell Action dietary guidance — evidence-based approach to reducing histamine load
SIGHI histamine compatibility list — detailed food compatibility chart used by specialists worldwide
Low Histamine Chef — meal planning, recipes, and practical strategies for day-to-day living
Healing Histamine — comprehensive blog with recipes, research summaries, and supplement guidance
AllergyEats — restaurant finder for patients with food sensitivities and allergies
Expert interviews and patient stories focused on MCAS diagnosis, treatment, and daily management
Dr. Linda Bluestein's show covering hEDS, MCAS, POTS and the full triad — highly recommended for Veros patients
Dysautonomia International's podcast — covers POTS, MCAS overlap, and autonomic dysfunction extensively
Evidence-based immunology podcast covering mast cell disorders, biologics, and immune-mediated conditions
Patient-focused podcast on living with chronic illness including MCAS, hEDS, and dysautonomia
Stories and interviews from people living with invisible chronic illness including mast cell disorders
Current peer-reviewed literature on MCAS diagnosis, pathophysiology, and treatment
Leading journal publishing MCAS clinical studies and treatment guidelines
Open-access journal with freely readable MCAS and mast cell research articles
Online communities can be a valuable source of peer support, practical tips, and community. Always verify medical information with your Veros provider — community advice varies in accuracy.
Large patient community for sharing experiences, tips, and emotional support
Official group connected to The Mast Cell Disease Society
Community specifically for patients navigating the hEDS + MCAS + POTS triad
Active Reddit community with patient discussions, treatment experiences, and research sharing
Moderated health community with MCAS-specific forums and peer support
Broader community for complex chronic illness patients including those with MCAS triad
(303) 224-4900 · veroshealth.com
hEDS is a heritable connective tissue disorder caused by defects in collagen — the protein that gives structure to joints, skin, blood vessels, and organs. Connective tissue is too lax, leading to joint hypermobility and wide-ranging systemic effects.
hEDS is the most common EDS subtype and is diagnosed clinically. It frequently co-occurs with MCAS, POTS, and dysautonomia — which is why a multisystem approach at Veros is essential.
hEDS frequently overlaps with MCAS and autoimmune conditions. A thorough immune workup helps identify treatable co-occurring drivers.
Coordination of a comprehensive, non-opioid-first pain strategy tailored to your specific joint and soft tissue pattern.
If you have overlapping mast cell activation or POTS, we treat these alongside your hEDS — they are part of the same picture.
PT specializing in hypermobility, genetics, cardiology (POTS), and GI (gastroparesis) coordinated through your Veros team.
You are not "just flexible." hEDS causes real, measurable pathology. Your symptoms are valid and treatable. Understanding your condition — including how MCAS and POTS overlap — is one of the most powerful tools you have for managing it.
The Ehlers-Danlos Society — diagnosis criteria, research, community
Dysautonomia International — POTS and autonomic dysfunction
Mast Cell Disease Society — for MCAS overlap management
(303) 224-4900 · immunehealth.com
HAE is a rare genetic disorder causing sudden, severe episodes of swelling beneath the skin or in the lining of internal organs. It is driven by overproduction of bradykinin due to low or dysfunctional C1-inhibitor protein.
Important: HAE is not caused by histamine — antihistamines and epinephrine do NOT stop HAE attacks. Proper on-demand therapy is essential.
⚠ Throat swelling is life-threatening. If you feel throat tightness during an attack, use your on-demand medication immediately and go to the emergency room. Do not wait to see if it resolves on its own.
Icatibant (Firazyr), C1-INH concentrate (Berinert, Ruconest), or ecallantide to stop active attacks quickly. We will train you to self-administer.
C1-INH concentrate before high-risk procedures or surgeries to prevent peri-operative attacks.
Lanadelumab (Takhzyro) or berotralstat (Orladeyo) for patients with frequent attacks — can dramatically reduce attack frequency and severity.
Every HAE patient leaves Veros with a personalized written attack protocol, emergency medications, and full self-injection training from our nursing team.
US Hereditary Angioedema Association — patient support and advocacy
HAE International — global resources and patient community
HAE Attack Diary and patient tools from HAEA
(303) 224-4900 · immunehealth.com